THE HANESSIAN GROUP
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Stephen Hanessian


CONTACT INFORMATION

(514) 343-6738
(514) 343-5728  
 (FAX)
stephen.hanessian@umontreal.ca

AFFILIATION   

                              ● Department of Chemistry, University of Montreal
                              ● ​Ionis Pharmaceuticals Research Chair
                              ● NSERC/ Servier Senior Industrial Research Chair

1960                      PhD Ohio State University (with Prof. M. L. Wolfrom)
1961-1968             Parke Davis & Co., Ann Arbor, Michigan
1969-1970             University of Montreal, Associate Professor
1970-1979             University of Montreal, Professor
1979-2003             McConnell Professor of Chemistry
1973-present         Invited visiting professorships: Paris, Rochester, MIT, Strasbourg, Lyon, Rome, Siena
1990-1995             NSERCC - Chair in Medicinal Chemistry
2000-2006             Adjunct Professor of Chemistry and Chemical Biology, University of California, Irvine
2003-present         Ionis Pharmaceuticals Research Chair
2005-2012             Achaogen Research Chair
2006-present         Distinguished Professor, Departments of Chemistry, Pharmaceutical Sciences, and Pharmacology at the                                              University of California, Irvine 
2006-present         Director of the Medicinal Chemistry and Pharmacology (MCP) Graduate Program at the University of California,                                  Irvine
2018-2023             NSERC/ Servier Senior Industrial Research Chair


AWARDS

1974     Merck Sharpe & Dohme Award (Chemical Institute of Canada)
1982     C.S. Hudson Award (American Chemical Society)
1987     Urgel-Archambault Award, Quebec Association for the Advancement of Science
1988     CIC Palladium Medal (Chemical Institute of Canada)
1988     Alfred Bader Award in Organic Chemistry (Canadian Society for Chemistry)
1988     Fellow, Royal Society of Canada
1989     Fellow, Killam Foundation
1990     NSERCC - Chair in Medicinal Chemistry
1991     Bell Canada-Forum Award
1992     E. Smissman Medal, University of Kansas
1993     M.L. Wolfrom Award (American Chemical Society)
1996     A.C. Cope Scholar Award (American Chemical Society)
1996     Canada Gold Medal for Science and Engineering
1996     Prix Marie-Victorin, Quebec Science Prize
1996     Science Personality of the Year (La Presse)
1997     Killam Memorial Prize (Natural Sciences)
1997     Compagnon Lavoisier (Quebec Order of Chemists)
1998     Officer of the Order of Canada
2001     Doctorate Honoris Causa, University of Siena, Italy
2001     Bernard Belleau Award in Medicinal Chemistry (CSC)
2001     Doctorate Honoris Causa, University of Moncton, NB, Canada
2002     Queen Elisabeth Golden Jubilee Medal
2003     Ionis Pharmaceuticals Research Chair
2006     Doctorate Honoris Causa, University of Urbino, Italy
2008     Ionis Pharmaceuticals Research Chair
2008     Elected Foreign Member, National Academy of Sciences, Republic of Armenia
2011     First FQRNT Quebec Science Prize
2012     Ernest Guenther Award in Natural Products, (American Chemical Society)
2012     IUPAC-Richter Prize in Medicinal Chemistry
2012     Montreal In Vivo Award

RESEARCH INTERESTS

The design and synthesis of drug prototypes, total synthesis of medicinally important natural products, asymmetric synthesis, supramolecular assembly, peptidomimetics, glycomimetics, morphinomimetics, amino acids, carbohydrates, ligand design for catalysis and methodology, aspects of chemical biology and chemoproteomics.
Current projects: 
  • New methodologies in chemical proteomics to study the interaction of synthetic cytotoxic sphingolipids with target proteins.
  • Ways to potentiate antisense oligonucleotide activity and delivery.
  • Synthesis of constrained azacycles to probe CNS receptor interactions.
  • Peptido- and glycomimetics to validate revelant enzyme active site interactions.
  • Total synthesis and study of pharmacophoric elements of lignan, quinolone, and Daphniphyllum alkaloid bioactive natural products as anticancer, antiparasitic, antibiotic, and antifeedant agents.
  • Reagent and catalyst design for asymmetric synthesis.

Consulting

Pharmaceutical, Biotech and Agrochemical Industries  (Canada, USA, Europe)

Publications

567

Patents

51

Monographs

- Total Synthesis of Natural Products:  The 'Chiron' Approach, Pergamon, 1983
- Preparative Carbohydrate Chemistry, Marcel Dekker Inc., 1997
- Design and Strategy in Organic Synthesis: From the Chiron Approach to Catalysis, VCH, August 2013 (794 pages) 
- Natural Products in Medicinal Chemistry, 16 Chapters, S. Hanessian Editor. Wiley-VCH, March 2014 (630 pages)

PLENARY LECTURES

2019     ACS National Meeting Orlando,USA, Guenther Award speaker, April 1
​             Medicinal Chemistry Symposium, Chemical Institute of Canada Meeting, June 2
             ACS National Meeting, San Diego, USA, Carbohydrate Division, August 25

2018     Symposium honoring M. Kuehne, University of Vermont, USA
             French American Symposium, Orléans, France
             Symposium honoring Victor Snieckus, Hamilton, Ontario, Canada,

2017     Medicinal Chemistry Symposium, University of California, Irvine, CA,  USA
             Gordon Research Conference Reactions and Processes, Stonehill College, MA, USA
​
2016     European Workshop on Drug Synthesis, Siena, Italy
             Organic Chemistry Conference, Las Vegas, Nevada, USA
             8th Central European Conference ‘Chemistry towards Biology’, Brno, Czech Republic
             Pharmaceutical Chemistry Conference, Frankfurt, Germany
             World Chemistry Conference, Toronto, Canada
             Ischia School of Advanced Organic Chemistry, Ischia, Italy

2015    First Sidney Hecht Endowed Lecture, University of Virginia, USA
            European Medicinal Chemistry Conference, Athens, Greece
            14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria
            250th ACS National Meeting, Boston, USA          
            Intl. Congress on the Chemistry of Antibiotics and other Bioactive Compounds, Galveston,
            Texas

2014    2nd International Congress on Bacteriology and Infectious Diseases, Chicago, USA
            LTOS conference, Brock University, Ontario, Canada                       
            Ischia School of Advanced Organic Chemistry, Ischia, Italy
            Canadian Society for Chemistry, Vancouver, Canada
            European Workshop on Drug Synthesis, Siena, Italy
            Florida Heterocyclic and Synthetic Conference, Gainesville, Fl., USA

2013    Canadian Institute of Chemistry National meeting (CIC), Quebec City
            ArmChemfront Conference, Yerevan, Armenia

2012    ACS Guenther Award Symposium, San Diego, USA
            European Workshop in Drug Synthesis, Siena, Italy
            ICPC Conference on Organophosphorus Chemistry, Rotterdam, Netherlands
            Ischia School of Advanced Organic Chemistry, Ischia, Italy
            European Conference in Medicinal Chemistry, Berlin Germany

2011    Congrès de l'ACFAS, Université de Sherbrooke, QC, Canada
            Keynote Lecture CIC Meeting, Montreal, QC, Canada
            Antibiotic Symposium, CIC Meeting, Montreal, QC, Canada
            IIT Lecture, Genoa, Italy

1970-present: Over 500 invited and plenary lectures (academia and industries)
 

 
Editorial and Professional Activities
 
Member, Advisory Board Several Journals, Conferences, Biotech industry

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